The Type VI secretion system: a versatile bacterial weapon

S Coulthurst - Microbiology, 2019 - microbiologyresearch.org
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

Activity, delivery, and diversity of Type VI secretion effectors

D Jurėnas, L Journet - Molecular Microbiology, 2021 - Wiley Online Library
The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …

An overview of anti-eukaryotic T6SS effectors

J Monjarás Feria, MA Valvano - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine
employed by many Gram-negative bacterial species to translocate, in a contact-dependent …

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

F Navarro-Garcia, F Ruiz-Perez, Á Cataldi… - Frontiers in …, 2019 - frontiersin.org
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage
tissue sites, and evade the immune system. One essential strategy of Gram-negative …

Structure and activity of the type VI secretion system

Y Cherrak, N Flaugnatti, E Durand, L Journet… - Microbiology …, 2019 - Am Soc Microbiol
The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like
mechanism to inject effectors into target cells. The injection apparatus is composed of a …

Contact-dependent interbacterial antagonism mediated by protein secretion machines

TA Klein, S Ahmad, JC Whitney - Trends in microbiology, 2020 - cell.com
To establish and maintain an ecological niche, bacteria employ a wide range of pathways to
inhibit the growth of their microbial competitors. Some of these pathways, such as those that …

Assembly and subcellular localization of bacterial type VI secretion systems

J Wang, M Brodmann, M Basler - Annual review of microbiology, 2019 - annualreviews.org
Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even
across membranes of neighboring cells to influence their environment, prevent predation …

The ecological impact of a bacterial weapon: microbial interactions and the Type VI secretion system

R Gallegos-Monterrosa… - FEMS Microbiology …, 2021 - academic.oup.com
Bacteria inhabit all known ecological niches and establish interactions with organisms from
all kingdoms of life. These interactions are mediated by a wide variety of mechanisms and …

Good gone bad: one toxin away from disease for Bacteroides fragilis

E Valguarnera, JB Wardenburg - Journal of molecular biology, 2020 - Elsevier
The human gut is colonized by hundreds of trillions of microorganisms whose acquisition
begins during early infancy. Species from the Bacteroides genus are ubiquitous …

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

DF Gauto, LF Estrozi, CD Schwieters, G Effantin… - Nature …, 2019 - nature.com
Atomic-resolution structure determination is crucial for understanding protein function. Cryo-
EM and NMR spectroscopy both provide structural information, but currently cryo-EM does …