The impact of systemic inflammation on Alzheimer's disease pathology

J **e, L Van Hoecke, RE Vandenbroucke - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

The human oral microbiome in health and disease: from sequences to ecosystems

JR Willis, T Gabaldón - Microorganisms, 2020 - mdpi.com
The human oral cavity is home to an abundant and diverse microbial community (ie, the oral
microbiome), whose composition and roles in health and disease have been the focus of …

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

Z Zhang, D Liu, S Liu, S Zhang, Y Pan - Frontiers in cellular and …, 2021 - frontiersin.org
Periodontal disease is a chronic infectious disease associated with a variety of bacteria,
which can cause damage to the periodontal support structure and affect a variety of systemic …

How can dementia and disability be prevented in older adults: where are we today and where are we going?

I Lisko, J Kulmala, M Annetorp… - Journal of internal …, 2021 - Wiley Online Library
Ageing of the population, together with population growth, has brought along an ample
increase in the number of older individuals living with dementia and disabilities. Dementia is …

Time to test antibacterial therapy in Alzheimer's disease

F Panza, M Lozupone, V Solfrizzi, M Watling… - Brain, 2019 - academic.oup.com
Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …

Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals

LP Jahromi, G Fuhrmann - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicle (EV)-mediated communication between proximal and distant cells is a
highly conserved characteristic in all of the life domains, including bacteria. These vesicles …

Diet and Alzheimer's dementia–Nutritional approach to modulate inflammation

K Szczechowiak, BS Diniz, J Leszek - Pharmacology Biochemistry and …, 2019 - Elsevier
Background Alzheimer's disease (AD) is the most common neurodegenerative disease
causing dementia in the elderly population. Due to the fact that there is still no cure for …

Armed to the teeth—the oral mucosa immunity system and microbiota

M Ptasiewicz, E Grywalska, P Mertowska… - International Journal of …, 2022 - mdpi.com
The oral cavity is inhabited by a wide spectrum of microbial species, and their colonization is
mostly based on commensalism. These microbes are part of the normal oral flora, but there …

The links between cardiovascular diseases and Alzheimer's disease

J Leszek, EV Mikhaylenko, DM Belousov… - Current …, 2021 - ingentaconnect.com
The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …

Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment

S Wei, W Peng, Y Mai, K Li, W Wei, L Hu… - Journal of cellular …, 2020 - Wiley Online Library
Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota
(GM). The GM is well‐known to be involved in the pathological process of Alzheimer's …