Water determines the structure and dynamics of proteins
Water is an essential participant in the stability, structure, dynamics, and function of proteins
and other biomolecules. Thermodynamically, changes in the aqueous environment affect …
and other biomolecules. Thermodynamically, changes in the aqueous environment affect …
Water dynamics in the hydration shells of biomolecules
The structure and function of biomolecules are strongly influenced by their hydration shells.
Structural fluctuations and molecular excitations of hydrating water molecules cover a broad …
Structural fluctuations and molecular excitations of hydrating water molecules cover a broad …
Effects of molecular crowding on the structures, interactions, and functions of nucleic acids
S Nakano, D Miyoshi, N Sugimoto - Chemical reviews, 2014 - ACS Publications
Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …
of Watson− Crick base pairs. Since the base pairing enables the highly selective …
Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm
Biological macromolecules function in highly crowded cellular environments. The structure
and dynamics of proteins and nucleic acids are well characterized in vitro, but in vivo …
and dynamics of proteins and nucleic acids are well characterized in vitro, but in vivo …
Simulation studies of amyloidogenic polypeptides and their aggregates
Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …
Molecular crowding: the history and development of a scientific paradigm
It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …
crowded environment, that is, an environment populated by numerous different molecules …
Crowding in cellular environments at an atomistic level from computer simulations
The effects of crowding in biological environments on biomolecular structure, dynamics, and
function remain not well understood. Computer simulations of atomistic models of …
function remain not well understood. Computer simulations of atomistic models of …
Soft interactions and crowding
The intracellular milieu is complex, heterogeneous and crowded—an environment vastly
different from dilute solutions in which most biophysical studies are performed. The crowded …
different from dilute solutions in which most biophysical studies are performed. The crowded …
Molecular crowding: Physiologic sensing and control
AR Subramanya… - Annual Review of …, 2024 - annualreviews.org
The cytoplasm is densely packed with molecules that contribute to its nonideal behavior.
Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and …
Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and …
Stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells
S Takahashi, N Sugimoto - Chemical Society Reviews, 2020 - pubs.rsc.org
Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …
These folding and unfolding behaviours are also the basis for various technical applications …