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Eph receptors and ephrins in cancer: bidirectional signalling and beyond
The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …
Therapeutic targeting of EPH receptors and their ligands
Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …
regenerative diseases are increasingly being recognized. In particular, the complex roles of …
Eph/ephrin molecules—a hub for signaling and endocytosis
The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …
extensive cell–cell communication to ensure that different cells proliferate, migrate …
Eph receptors in cancer
Eph receptor tyrosine kinases play critical functions during development, in the formation of
tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine …
tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine …
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
The evolution of colorectal cancer suggests the involvement of many genes. To identify new
drivers of intestinal cancer, we performed insertional mutagenesis using the Slee** …
drivers of intestinal cancer, we performed insertional mutagenesis using the Slee** …
Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis
O Salvucci, G Tosato - Advances in cancer research, 2012 - Elsevier
Eph receptor tyrosine kinases and their Ephrin ligands represent an important signaling
system with widespread roles in cell physiology and disease. Receptors and ligands in this …
system with widespread roles in cell physiology and disease. Receptors and ligands in this …
Modeling intestinal stem cell function with organoids
T Takahashi, K Fujishima, M Kengaku - International journal of molecular …, 2021 - mdpi.com
Intestinal epithelial cells (IECs) are crucial for the digestive process and nutrient absorption.
The intestinal epithelium is composed of the different cell types of the small intestine (mainly …
The intestinal epithelium is composed of the different cell types of the small intestine (mainly …
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel
development and vascular remodeling. In addition, several reports suggest that this receptor …
development and vascular remodeling. In addition, several reports suggest that this receptor …
The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells
I Mertens-Walker, BC Fernandini, MSN Maharaj… - BMC cancer, 2015 - Springer
Abstract Background The EphB4 receptor tyrosine kinase is overexpressed in many cancers
including prostate cancer. The molecular mechanisms by which this ephrin receptor …
including prostate cancer. The molecular mechanisms by which this ephrin receptor …
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer
Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types,
although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation …
although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation …