The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients
to generate reducing equivalents for energy production and critical metabolites for …

There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA),
a highly lethal malignancy with increasing incidence and poor prognosis. Although targeting …

Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …

Metastasis requires cancer cells to undergo metabolic changes that are poorly understood,–
. Here we show that metabolic differences among melanoma cells confer differences in …

Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate
contributes to energy metabolism in living tumors. We previously reported that human non …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …