Technological advances enabling massively parallel measurement of biological features—
such as microarrays, high-throughput sequencing and mass spectrometry—have ushered in …

Almost all biomedical research to date has relied upon mean measurements from cell
populations, however it is well established that what it is observed at this macroscopic level …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

Most spatial transcriptomics technologies are limited by their resolution, with spot sizes
larger than that of a single cell. Although joint analysis with single-cell RNA sequencing can …

Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …

Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …

Legumes form symbiosis with rhizobium leading to the development of nitrogen-fixing
nodules. By integrating single-nucleus and spatial transcriptomics, we established a cell …

The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).
Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics …

Abstract Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in
autoimmune conditions, including of the CNS, IL-12 reduces inflammation. The underlying …

Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …