With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

The outer lipopolysaccharide (LPS) membrane of Gram-negative bacteria forms the main
barrier for transport of antimicrobial molecules into the bacterial cell. In this study we develop …

Lipid nanoparticles (LNPs) are a leading biomimetic drug delivery platform due to their
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …

Recent advances in molecular dynamics (MD) simulations have led to rapid improvement in
our understanding of the molecular details of the outer membranes (OMs) of Gram-negative …

Polymyxins are increasingly used as the last-line therapeutic option for the treatment of
infections caused by multidrug-resistant Gram-negative bacteria. However, efforts to address …

The rise in multi-drug resistant Gram-negative bacterial infections has led to an increased
need for “last-resort” antibiotics such as polymyxins. However, the emergence of polymyxin …

Polymyxins, critical last-resort antibiotics, impact the distribution of membrane-bound
divalent cations in the outer membrane of Gram-negative bacteria. We employed atomistic …

Membrane-active peptides (MAPs) exhibit great potential in biomedical applications due to
their unique ability to overcome the cell membrane barrier. However, the interactions …

Bacterial infections have become a global public health problem in recent decades, mainly
due to infections caused by Gram-negative bacteria with antibiotic resistance profiles, which …

Antimicrobial peptides (AMP), positively charged polypeptides, are now extensively studied
in the world to develop efficient drugs against extremely resistant bacterial strains. By …