Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient
oxidative phosphorylation (OXPHOS) and elevated electron leakage from the electron …

Aging is a natural process that leads to time-related changes and a decrease in cognitive
abilities, executive functions, and attention. In neuronal aging, brain cells struggle to …

Aging disrupts brain function, leading to cognitive decline and neurodegenerative diseases.
Senescent astrocytes, a hallmark of aging, contribute to this process through unknown …

Phaeodactylum tricornutum (PT) is a microalgae extract that contains fucoxanthin and has
been shown to enhance cognitive function in younger populations. The present study …

Mitochondria are key organelles for the optimal function of the cell. Among their many
functions, they maintain protein homeostasis through their own proteostatic machinery …

Postoperative neurocognitive dysfunction (PND) is a prevalent and debilitating complication
in elderly surgical patients, characterized by persistent cognitive decline that negatively …

Parkinson's disease (PD) involves the disruption of brain energy homeostasis. This
encompasses broad-impact factors such as mitochondrial dysfunction, impaired glycolysis …

Among the non-motor symptoms associated with Parkinson's disease (PD), cognitive
impairment is one of the most common and disabling. It can occur either early or late during …

Aging is associated with intestinal dysbiosis, a condition characterized by diminished
microbial biodiversity and inflammation. This leads to increased vulnerability to …

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the
pathophysiology of various cerebral pathologies, particularly neurodegenerative disorders …