Natural products as platforms to overcome antibiotic resistance
Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …
A literature perspective on the pharmacological applications of yohimbine
Introduction: Phytochemicals have garnered much attention because they are useful in
managing several human diseases. Yohimbine is one such phytochemical with significant …
managing several human diseases. Yohimbine is one such phytochemical with significant …
Chemical evolution of natural product structure
M Grigalunas, S Brakmann… - Journal of the American …, 2022 - ACS Publications
Natural products are the result of Nature's exploration of biologically relevant chemical
space through evolution and an invaluable source of bioactive small molecules for chemical …
space through evolution and an invaluable source of bioactive small molecules for chemical …
Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis
E Llabani, RW Hicklin, HY Lee, SE Motika… - Nature …, 2019 - nature.com
The chemical diversification of natural products provides a robust and general method for
the creation of stereochemically rich and structurally diverse small molecules. The resulting …
the creation of stereochemically rich and structurally diverse small molecules. The resulting …
Deconstructive functionalizations of unstrained carbon–nitrogen cleavage enabled by difluorocarbene
J Su, X Ma, Z Ou, Q Song - ACS Central Science, 2020 - ACS Publications
Transition-metal-or oxidant-promoted deconstructive functionalizations of noncyclic carbon–
nitrogen bonds are well established, usually only leaving one moiety functionalized toward …
nitrogen bonds are well established, usually only leaving one moiety functionalized toward …
Gold‐catalyzed asymmetric intramolecular cyclization of N‐allenamides for the synthesis of chiral tetrahydrocarbolines
Y Wang, P Zhang, X Di, Q Dai, ZM Zhang… - Angewandte …, 2017 - Wiley Online Library
Highly enantioselective gold‐catalyzed intramolecular cyclization of N‐allenamides was
implemented by utilizing a designed chiral sulfinamide phosphine ligand (PC‐Phos). This …
implemented by utilizing a designed chiral sulfinamide phosphine ligand (PC‐Phos). This …
C–H bond functionalization of amines: a graphical overview of diverse methods
S Dutta, B Li, DRL Rickertsen, DA Valles, D Seidel - SynOpen, 2021 - thieme-connect.com
Thieme E-Journals - SynOpen / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …
Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer
Chemical synthesis based on the skeletal variation has been prolifically utilized as an
attractive approach for modification of molecular properties. Given the ubiquity of unstrained …
attractive approach for modification of molecular properties. Given the ubiquity of unstrained …
Guided by evolution: from biology oriented synthesis to pseudo natural products
Covering: up to 2020 Natural products (NPs) provide inspiration for the design of biologically
active compounds and libraries. In this review, we cover several experimental and in silico …
active compounds and libraries. In this review, we cover several experimental and in silico …
Re-engineering natural products to engage new biological targets
SE Motika, PJ Hergenrother - Natural product reports, 2020 - pubs.rsc.org
Covering: up to 2020 Natural products have a long history in drug discovery, with their
inherent biological activity often tailored by medicinal chemists to arrive at the final drug …
inherent biological activity often tailored by medicinal chemists to arrive at the final drug …