Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Zinc complexes with nitrogen donor ligands as anticancer agents

M Porchia, M Pellei, F Del Bello, C Santini - Molecules, 2020 - mdpi.com
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …

Novel bifluorescent Zn (II)–cryptolepine–cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells

ZF Wang, XF Zhou, QC Wei, QP Qin, JX Li… - European Journal of …, 2022 - Elsevier
Four novel bifluorescent Zn (II)–cryptolepine–cyclen complexes, namely [Zn (BQTC)] Cl 2
(Zn (BQTC)),[Zn (BQA)(Cur) Cl](Zn (BQACur)),[Zn (TC)] Cl 2 (Zn (TC)), and [Zn (AP)(Cur) …

Discovery of triaromatic flexible agents bearing 1, 2, 3-Triazole with selective and potent anti-breast cancer activity and CDK9 inhibition supported by molecular …

SK Ihmaid, A Aljuhani, M Alsehli, N Rezki… - Journal of Molecular …, 2022 - Elsevier
This study reports an efficient and convenient click synthesis of novel series of chromene
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …

Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy

DA Guk, OO Krasnovskaya… - Russian Chemical …, 2021 - iopscience.iop.org
The review summarizes the data on the structures and methods for the synthesis of
compounds with anticancer activity based on biogenic metals, which can replace platinum …

Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn (II) complexes

CP Matos, Y Addis, P Nunes, S Barroso, I Alho… - Journal of Inorganic …, 2019 - Elsevier
Zinc (II) complexes bearing N-salicylideneglycinate (Sal-Gly) and 1, 10-phenanthroline
(phen) or phenanthroline derivatives [NN= 5-chloro-1, 10-phenanthroline, 5-amine-1, 10 …

Monofunctional dimetallic Ru (η6-arene) complexes inhibit NOTCH1 signaling pathway and synergistically enhance anticancer effect in combination with cisplatin or …

N Wang, A Ali, Z Liu, H Chi, Z Lv, X Zhao… - European Journal of …, 2023 - Elsevier
Abstract ONS donor ligands L1-L4 were utilized in the preparation of monofunctional
dimetallic Ru (η6-arene) complexes (C1–C4). These ONS donor ligand based novel …

Mitochondria‐Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes

HM Li, MM Wang, Y Su, HB Fang, Z Su - ChemMedChem, 2024 - Wiley Online Library
Mitochondria, recognized as the cellular powerhouses, are indispensable organelles
responsible for crucial cellular processes, such as energy metabolism, material synthesis …

A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and …

Z Kazemi, N Moini, HA Rudbari… - Medicinal Research …, 2024 - Wiley Online Library
Chirality is a fundamental and widespread geometric structural property in living organisms
that most biomacromolecules including nucleic acids, proteins and enzymes, possess …

[HTML][HTML] Design of new Zn (II) pyrazine and pyridine derivatives based complexes as potential anticancer agents: from synthesis to structure

A Climova, E Pivovarova, M Szczesio, A Olczak… - Polyhedron, 2023 - Elsevier
The newly synthesized ligands based on pyrazine and pyridine derivatives and its Zn (II)
complexes were reported. Elemental analysis (EA), flame atomic absorption spectroscopy (F …