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Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
Zinc complexes with nitrogen donor ligands as anticancer agents
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …
Novel bifluorescent Zn (II)–cryptolepine–cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells
ZF Wang, XF Zhou, QC Wei, QP Qin, JX Li… - European Journal of …, 2022 - Elsevier
Four novel bifluorescent Zn (II)–cryptolepine–cyclen complexes, namely [Zn (BQTC)] Cl 2
(Zn (BQTC)),[Zn (BQA)(Cur) Cl](Zn (BQACur)),[Zn (TC)] Cl 2 (Zn (TC)), and [Zn (AP)(Cur) …
(Zn (BQTC)),[Zn (BQA)(Cur) Cl](Zn (BQACur)),[Zn (TC)] Cl 2 (Zn (TC)), and [Zn (AP)(Cur) …
Discovery of triaromatic flexible agents bearing 1, 2, 3-Triazole with selective and potent anti-breast cancer activity and CDK9 inhibition supported by molecular …
This study reports an efficient and convenient click synthesis of novel series of chromene
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …
Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy
DA Guk, OO Krasnovskaya… - Russian Chemical …, 2021 - iopscience.iop.org
The review summarizes the data on the structures and methods for the synthesis of
compounds with anticancer activity based on biogenic metals, which can replace platinum …
compounds with anticancer activity based on biogenic metals, which can replace platinum …
Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn (II) complexes
Zinc (II) complexes bearing N-salicylideneglycinate (Sal-Gly) and 1, 10-phenanthroline
(phen) or phenanthroline derivatives [NN= 5-chloro-1, 10-phenanthroline, 5-amine-1, 10 …
(phen) or phenanthroline derivatives [NN= 5-chloro-1, 10-phenanthroline, 5-amine-1, 10 …
Monofunctional dimetallic Ru (η6-arene) complexes inhibit NOTCH1 signaling pathway and synergistically enhance anticancer effect in combination with cisplatin or …
N Wang, A Ali, Z Liu, H Chi, Z Lv, X Zhao… - European Journal of …, 2023 - Elsevier
Abstract ONS donor ligands L1-L4 were utilized in the preparation of monofunctional
dimetallic Ru (η6-arene) complexes (C1–C4). These ONS donor ligand based novel …
dimetallic Ru (η6-arene) complexes (C1–C4). These ONS donor ligand based novel …
Mitochondria‐Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes
HM Li, MM Wang, Y Su, HB Fang, Z Su - ChemMedChem, 2024 - Wiley Online Library
Mitochondria, recognized as the cellular powerhouses, are indispensable organelles
responsible for crucial cellular processes, such as energy metabolism, material synthesis …
responsible for crucial cellular processes, such as energy metabolism, material synthesis …
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and …
Chirality is a fundamental and widespread geometric structural property in living organisms
that most biomacromolecules including nucleic acids, proteins and enzymes, possess …
that most biomacromolecules including nucleic acids, proteins and enzymes, possess …
[HTML][HTML] Design of new Zn (II) pyrazine and pyridine derivatives based complexes as potential anticancer agents: from synthesis to structure
A Climova, E Pivovarova, M Szczesio, A Olczak… - Polyhedron, 2023 - Elsevier
The newly synthesized ligands based on pyrazine and pyridine derivatives and its Zn (II)
complexes were reported. Elemental analysis (EA), flame atomic absorption spectroscopy (F …
complexes were reported. Elemental analysis (EA), flame atomic absorption spectroscopy (F …