Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Q Lu, D Kou, S Lou, M Ashrafizadeh, AR Aref… - Journal of Hematology & …, 2024‏ - Springer
Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

H Tian, T Zhang, S Qin, Z Huang, L Zhou, J Shi… - Journal of hematology & …, 2022‏ - Springer
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

R Liu, C Luo, Z Pang, J Zhang, S Ruan, M Wu… - Chinese chemical …, 2023‏ - Elsevier
Decades have passed since the first nanoparticles-base medicine was approved for human
cancer treatment, and the research and development of nanoparticles for drug delivery are …

Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy

S Peng, F **ao, M Chen, H Gao - Advanced Science, 2022‏ - Wiley Online Library
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …

[HTML][HTML] The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

M Yang, J Li, P Gu, X Fan - Bioactive materials, 2021‏ - Elsevier
The tumor development and metastasis are closely related to the structure and function of
the tumor microenvironment (TME). Recently, TME modulation strategies have attracted …

The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities

CM Neophytou, M Panagi, T Stylianopoulos… - Cancers, 2021‏ - mdpi.com
Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021‏ - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Three-dimensional spheroids as in vitro preclinical models for cancer research

B Pinto, AC Henriques, PMA Silva, H Bousbaa - Pharmaceutics, 2020‏ - mdpi.com
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …

Nanotechnology for boosting cancer immunotherapy and remodeling tumor microenvironment: the horizons in cancer treatment

S Gao, X Yang, J Xu, N Qiu, G Zhai - ACS nano, 2021‏ - ACS Publications
Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

Advances in the application of metal oxide nanozymes in tumor detection and treatment

C Cheng, H Wang, J Zhao, Y Wang, G Zhao… - Colloids and Surfaces B …, 2024‏ - Elsevier
Natural enzymes play an important role to support the regular life activities of the human
body. However, the application conditions of natural enzymes are harsh and there are …