Applications of tandem mass spectrometry (MS/MS) in protein analysis for biomedical research

AN Neagu, M Jayathirtha, E Baxter, M Donnelly… - Molecules, 2022 - mdpi.com
Mass Spectrometry (MS) allows the analysis of proteins and peptides through a variety of
methods, such as Electrospray Ionization-Mass Spectrometry (ESI-MS) or Matrix-Assisted …

Biological mass spectrometry enables spatiotemporal 'omics: From tissues to cells to organelles

LR Pade, KE Stepler, EP Portero… - Mass spectrometry …, 2024 - Wiley Online Library
Biological processes unfold across broad spatial and temporal dimensions, and
measurement of the underlying molecular world is essential to their understanding …

Experimental upregulation of developmentally downregulated ribosomal protein large subunits 7 and 7A promotes axon regeneration after injury in vivo

J **ng, WC Theune, A Lukomska, MP Frost… - Experimental …, 2023 - Elsevier
Ribosomal proteins are involved in neurodevelopment and central nervous system (CNS)
disease and injury. However, the roles of specific ribosomal protein subunits in …

Characterization of lncRNA and mRNA profiles in the process of repairing peripheral nerve defects with cell-matrixed nerve grafts

S Wang, W Wang, H Wang, Y Yang, X Liu, Y Zhu… - BMC genomics, 2024 - Springer
Background Decellularized extracellular matrix (dECM) is an intriguing natural biomaterial
that has garnered significant attention due to its remarkable biological properties. In our …

Insight into protein synthesis in axon regeneration

S Wu, J Xu, Y Dai, B Yu, J Zhu, S Mao - Experimental Neurology, 2023 - Elsevier
Successful axon regeneration is crucial for the treatment of numerous nerve injuries and
neurodegenerative diseases, which requires adequate and accurate protein synthesis …

Functional genomics of axons and synapses to understand neurodegenerative diseases

A Di Paolo, J Garat, G Eastman, J Farias… - Frontiers in Cellular …, 2021 - frontiersin.org
Functional genomics studies through transcriptomics, translatomics and proteomics have
become increasingly important tools to understand the molecular basis of biological systems …

RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration

X Zhou, Y Lv, H **e, Y Li, C Liu, M Zheng… - Neural Regeneration …, 2024 - journals.lww.com
Exosomes exhibit complex biological functions and mediate a variety of biological
processes, such as promoting axonal regeneration and functional recovery after injury. Long …

The Trail of axonal protein Synthesis: Origins and current functional Landscapes

J Garat, A Di Paolo, G Eastman, PE Castillo… - Neuroscience, 2025 - Elsevier
Local protein synthesis (LPS) in axons is now recognized as a physiological process,
participating both in the maintenance of axonal function and diverse plastic phenomena. In …

Quantitative mass spectrometry analysis of the injured proximal and distal human digital nerve ends

D Frostadottir, C Welinder, R Perez… - Frontiers in Molecular …, 2024 - frontiersin.org
Introduction Proteomic analysis of injured human peripheral nerves, particularly focusing on
events occurring in the proximal and distal nerve ends, remains relatively underexplored …

Cellular proteomic profiling using proximity labeling by TurboID-NES in microglial and neuronal cell lines

S Sunna, C Bowen, H Zeng, S Rayaprolu… - Molecular & Cellular …, 2023 - ASBMB
Different brain cell types play distinct roles in brain development and disease. Molecular
characterization of cell-specific mechanisms using cell type–specific approaches at the …