Scalable sequence–function studies have enabled the systematic analysis and cataloging of
hundreds of thousands of coding and noncoding genetic variants in the human genome …

Background Computational variant effect predictors offer a scalable and increasingly
reliable means of interpreting human genetic variation, but concerns of circularity and bias …

A major challenge in protein design is to augment existing functional proteins with multiple
property enhancements. Altering several properties likely necessitates numerous primary …

Accurate interpretation of human genetic data is critical for optimizing outcomes in the era of
genomic medicine. Powerful methods for testing genetic variants for functional effects are …

Given the vast number of disorders that originate from mutations in DNA, the problem of
distinguishing between those that are causative of disease (ie are “pathogenic”) and those …