Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …

Genetic screens are powerful tools for the functional annotation of genomes. In the context of
multicellular organisms, interrogation of gene function is greatly facilitated by methods that …

Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type
I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this …

Ketone bodies are bioactive metabolites that function as energy substrates, signaling
molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in …

Fingerprints are of long-standing practical and cultural interest, but little is known about the
mechanisms that underlie their variation. Using genome-wide scans in Han Chinese …

During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …

Background: Ischemic heart disease is a leading cause of heart failure and despite
advanced therapeutic options, morbidity and mortality rates remain high. Although acute …

Progress in science requires standardized assays whose results can be readily shared,
compared, and reproduced across laboratories. Reproducibility, however, has been a …

Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and
removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the …