Iron deficiency anemia (IDA) has reached epidemic proportions in develo** countries and
has become a major global public health problem, affecting mainly 0–5-year-old children …

Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …

Guanine-rich DNA sequences occur throughout the human genome and can transiently form
G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …

Iron deficiency is globally prevalent, causing an array of developmental, haematological,
immunological, neurological, and cardiometabolic impairments, and is associated with …

Transcription-replication conflicts (TRCs) induce formation of cotranscriptional RNA: DNA
hybrids (R-loops) stabilized by G-quadruplexes (G4s) on the displaced DNA strand, which …

Damaging DNA is a current and efficient strategy to fight against cancer cell proliferation.
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …

A well-accepted hallmark of cancer is genomic instability, which drives tumorigenesis.
Therefore, understanding the molecular and cellular defects that destabilize chromosomal …

Ferroptosis is a novel form of regulated cell death trigged by various biological processes,
and p53 is involved in different ferroptosis regulations and functions as a crucial regulator …

Meiotic recombination between homologous chromosomes is initiated by the formation of
hundreds of programmed double-strand breaks (DSBs). Approximately 10% of these DSBs …