Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011‏ - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

[HTML][HTML] Mechanisms of perpetuation of atrial fibrillation in chronically dilated atria

J Eckstein, S Verheule, N de Groot, M Allessie… - Progress in biophysics …, 2008‏ - Elsevier
The progressive nature of atrial fibrillation (AF) has been demonstrated in numerous
experimental as well as clinical investigations. Electrical remodeling (shortening of atrial …

Clinical map** approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation

SM Narayan, DE Krummen… - Journal of …, 2012‏ - Wiley Online Library
Computational Map** of Rotors and Focal Impulses in Human AF. Introduction: The
perpetuating mechanisms for human atrial fibrillation (AF) remain undefined. Localized …

System and method for local electrophysiological characterization of cardiac substrate using multi-electrode catheters

DC Deno, RK Balachandran - US Patent 10,470,682, 2019‏ - Google Patents
(57) ABSTRACT A system for determining electrophysiological data com prising an
electronic control unit configured to acquire electrophysiology signals from a plurality of …

Loss of continuity in the thin epicardial layer because of endomysial fibrosis increases the complexity of atrial fibrillatory conduction

S Verheule, E Tuyls, A Gharaviri… - Circulation …, 2013‏ - ahajournals.org
Background—The transition from persistent to permanent atrial fibrillation (AF) is associated
with increased complexity of fibrillatory conduction. We have investigated the spatial …

Technical considerations for dominant frequency analysis

J Ng, AH Kadish, JJ Goldberger - Journal of cardiovascular …, 2007‏ - Wiley Online Library
Introduction: Dominant frequency (DF) analysis of atrial electrograms has been used to
characterize atrial fibrillation (AF). The aim of this study was to explore technical issues that …

Fibrillatory conduction in the atrial free walls of goats in persistent and permanent atrial fibrillation

S Verheule, E Tuyls, A van Hunnik… - Circulation …, 2010‏ - ahajournals.org
Background—Over a time course of months, the stability of atrial fibrillation (AF) gradually
increases and the efficacy of pharmacological cardioversion declines both in humans and in …

Systems and methods for using electrophysiology properties for classifying arrhythmia sources

DC Deno, RK Balachandran - US Patent 10,136,829, 2018‏ - Google Patents
(57) ABSTRACT A method for determining electrophysiology properties of tissue comprising
acquiring electrical signal data from a plurality of electrodes (130) of one or more catheters …

[HTML][HTML] A note on stress-driven anisotropic diffusion and its role in active deformable media

C Cherubini, S Filippi, A Gizzi, R Ruiz-Baier - Journal of Theoretical Biology, 2017‏ - Elsevier
We introduce a new model to describe diffusion processes within active deformable media.
Our general theoretical framework is based on physical and mathematical considerations …

Systems and methods for orientation independent sensing

DC Deno, RK Balachandran, S Massé - US Patent 10,194,994, 2019‏ - Google Patents
A system and method for obtaining an OIS coordinate frame comprising an electronic control
unit configured to deter mine a local 3D electric field loop, create a zero mean version of E (t) …