Pharmacological characterization of GPR55, a putative cannabinoid receptor
GPR55 has recently attracted much attention as another member of the cannabinoid family,
potentially explaining physiological effects that are non-CB1/CB2 mediated. However, the …
potentially explaining physiological effects that are non-CB1/CB2 mediated. However, the …
Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus
L Besser, E Chorin, I Sekler, WF Silverman… - Journal of …, 2009 - Soc Neuroscience
Zn2+ is coreleased with glutamate from mossy fiber terminals and can influence synaptic
function. Here, we demonstrate that synaptically released Zn2+ activates a selective …
function. Here, we demonstrate that synaptically released Zn2+ activates a selective …
The zinc sensing receptor, ZnR/GPR39, in health and disease
M Hershfinkel - International journal of molecular sciences, 2018 - mdpi.com
A distinct G-protein coupled receptor that senses changes in extracellular Zn2+,
ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most …
ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most …
How cellular Zn2+ signaling drives physiological functions
N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
A ratiometric, turn-on fluorosensor for specific detection of Zn2+ ions
A potentially active fluorescent chemosensor (E)-2-(((2-(1H-benzo [d] imidazol-2-yl) phenyl)
imino) methyl)-5-(diethylamino) phenol (BMDP) is developed by the condensation of 2-(2 …
imino) methyl)-5-(diethylamino) phenol (BMDP) is developed by the condensation of 2-(2 …
Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair
A role for Zn 2+ in accelerating wound healing is established, yet, the signaling pathways
linking Zn 2+ to tissue repair are not well known. We show that in the human HaCaT …
linking Zn 2+ to tissue repair are not well known. We show that in the human HaCaT …
[HTML][HTML] Zinc deficiency in men over 50 and its implications in prostate disorders
Research has been consistently showing the role of zinc (Zn) in prostate function. In this
article, we review the current literature on the anatomy and main functions of the prostate …
article, we review the current literature on the anatomy and main functions of the prostate …
The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon
L Cohen, I Sekler, M Hershfinkel - Cell death & disease, 2014 - nature.com
The intestinal epithelium is a renewable tissue that requires precise balance between
proliferation and differentiation, an essential process for the formation of a tightly sealed …
proliferation and differentiation, an essential process for the formation of a tightly sealed …
The zinc-sensing receptor GPR39 in physiology and as a pharmacological target
The G-protein coupled receptor GPR39 is abundantly expressed in various tissues and can
be activated by changes in extracellular Zn2+ in physiological concentrations. Previously …
be activated by changes in extracellular Zn2+ in physiological concentrations. Previously …
Bone and plasma citrate is reduced in osteoporosis
High concentration of citrate exists in bone of humans and all osteo-vertebrates, and citrate
incorporation imparts important biomechanical and other functional properties to bone …
incorporation imparts important biomechanical and other functional properties to bone …