Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development
Microcins are an understudied and poorly characterized class of antimicrobial peptides.
Despite the existence of only 15 examples, all identified from the Enterobacteriaceae …
Despite the existence of only 15 examples, all identified from the Enterobacteriaceae …
Lipids mediate supramolecular outer membrane protein assembly in bacteria
β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …
Force-generation by the trans-envelope Tol-Pal system
The Tol-Pal system spans the cell envelope of Gram-negative bacteria, transducing the
potential energy of the proton motive force (PMF) into dissociation of the TolB-Pal complex at …
potential energy of the proton motive force (PMF) into dissociation of the TolB-Pal complex at …
Tunable force transduction through the Escherichia coli cell envelope
The outer membrane (OM) of Gram-negative bacteria is not energised and so processes
requiring a driving force must connect to energy-transduction systems in the inner …
requiring a driving force must connect to energy-transduction systems in the inner …
Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions
(HSILs) as precursors to cancer in the anogenital area, and the microbiome is suggested to …
(HSILs) as precursors to cancer in the anogenital area, and the microbiome is suggested to …
Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope
Timely detection and repair of envelope damage are paramount for bacterial survival. The
Regulator of Capsule Synthesis (Rcs) stress response can transduce the stress signals …
Regulator of Capsule Synthesis (Rcs) stress response can transduce the stress signals …
Colicin E1 opens its hinge to plug TolC
The double membrane architecture of Gram-negative bacteria forms a barrier that is
impermeable to most extracellular threats. Bacteriocin proteins evolved to exploit the …
impermeable to most extracellular threats. Bacteriocin proteins evolved to exploit the …
Klebicin E, a pore-forming bacteriocin of Klebsiella pneumoniae, exploits the porin OmpC and the Ton system for translocation
X Zhao, W Wang, X Zeng, R Xu, B Yuan, W Yu… - Journal of Biological …, 2024 - jbc.org
Bacteriocins, which have narrow-spectrum activity and limited adverse effects, are promising
alternatives to antibiotics. In this study, we identified klebicin E (KlebE), a small bacteriocin …
alternatives to antibiotics. In this study, we identified klebicin E (KlebE), a small bacteriocin …
Proteolytic processing induces a conformational switch required for antibacterial toxin delivery
NL Bartelli, VJ Passanisi, K Michalska, K Song… - nature …, 2022 - nature.com
Many Gram-negative bacteria use CdiA effector proteins to inhibit the growth of neighboring
competitors. CdiA transfers its toxic CdiA-CT region into the periplasm of target cells, where …
competitors. CdiA transfers its toxic CdiA-CT region into the periplasm of target cells, where …
Structural constraints of pyocin S2 import through the ferripyoverdine receptor FpvAI
JD Goult, DCL Van, YV Taylor, PG Inns… - PNAS …, 2024 - academic.oup.com
TonB-dependent transporters (TBDTs) mediate energized transport of essential nutrients
into gram-negative bacteria. TBDTs are increasingly being exploited for the delivery of …
into gram-negative bacteria. TBDTs are increasingly being exploited for the delivery of …