Positioning of negative feedback loops within immune signaling pathways influences host fitness through noise in AMP expression

D Asgari, AT Tate - bioRxiv, 2024 - biorxiv.org
Signaling pathways depend on negative feedback loops (NFLs) to regulate internal noise.
Across diverse organisms, signaling pathways are regulated by NFLs that function at …

[HTML][HTML] How the Structure of Signaling Regulation Evolves: Insights from an Evolutionary Model

D Asgari, AT Tate - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
To remain responsive to environmental changes, signaling pathways attenuate their activity
with negative feedback loops (NFLs), where proteins produced upon stimulation …