Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …

For more than 50 years, ketamine has proven to be a safe anesthetic drug with potent
analgesic properties. The active enantiomer is S (+)‐ketamine. Ketamine is mostly …

Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in
glutamate-mediated neurotransmission have been increasingly documented in a range of …

Aims Ketamine remains an important medicine in both specialist anaesthesia and aspects of
pain management. At the same time, its use as a recreational drug has spread in many parts …

The discovery of the antidepressant effects of ketamine has opened a breakthrough
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …

From early embryonic development to adulthood, GABA release participates in the
construction of the mammalian cerebral cortex. The maturation of GABAergic …

NMDA receptors mediate excitatory postsynaptic potentials throughout the brain but,
paradoxically, NMDA receptor antagonists produce cortical excitation in humans and …

Rationale: Since the mid-1970s, cross-species translational studies of prepulse inhibition
(PPI) have increased at an astounding pace as the value of this neurobiologically …