The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mt DNA)‐binding
protein essential for genome maintenance. TFAM functions in determining the abundance of …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative
disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high …

Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain
containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to …

PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has
been highlighted for its role in early-onset Parkinson's disease. In recent years, an …

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder,
characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying …

Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a
cytoprotective protein that is dysregulated in inflammatory lung injury and …

The gene PINK1 [phosphatase and tensin homologue (PTEN)‐induced putative kinase 1]
encodes a serine/threonine kinase which was initially linked to the pathogenesis of a familial …

Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1) gene
encodes a serine/threonine kinase, which acts as a molecular sensor of mitochondrial …

It has been nearly a decade since the first landmark studies implicating familial recessive
Parkinson's disease genes in the regulation of selective mitochondrial autophagy. The …