As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the develo** and adult brain during homeostasis and …

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Epithelial organoids, such as those derived from stem cells of the intestine, have great
potential for modelling tissue and disease biology,,–. However, the approaches that are …

Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Macrophages are the first cells of the nascent immune system to emerge during embryonic
development. In mice, embryonic macrophages infiltrate develo** organs, where they …

Microglia are specialized brain-resident macrophages that arise from primitive macrophages
colonizing the embryonic brain. Microglia contribute to multiple aspects of brain …

Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological
malignancies. Macrophages have also gained attention as an immunotherapy owing to their …

The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Aberrant inflammation in the CNS has been implicated as a major player in the
pathogenesis of human neurodegenerative disease. We developed a new approach to …