Initial expectations for genome-wide association studies were high, as such studies
promised to rapidly transform personalized medicine with individualized disease risk …

Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

DNA methylation, an important type of epigenetic modification in humans, participates in
crucial cellular processes, such as embryonic development, X-inactivation, genomic …

Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …

We propose an extension to quantile normalization that removes unwanted technical
variation using control probes. We adapt our algorithm, functional normalization, to the …

Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

Although genome-wide association (GWA) studies for common variants have thus far
succeeded in explaining only a modest fraction of the genetic components of human …