Cis- and Trans-regulatory Effects on Gene Expression in a Natural Population of Drosophila melanogaster
Cis-and trans-regulatory mutations are important contributors to transcriptome evolution.
Quantifying their relative contributions to intraspecific variation in gene expression is …
Quantifying their relative contributions to intraspecific variation in gene expression is …
Widespread misregulation of inter-species hybrid transcriptomes due to sex-specific and sex-chromosome regulatory evolution
S Sánchez-Ramírez, JG Weiss, CG Thomas… - PLoS …, 2021 - journals.plos.org
When gene regulatory networks diverge between species, their dysfunctional expression in
inter-species hybrid individuals can create genetic incompatibilities that generate the …
inter-species hybrid individuals can create genetic incompatibilities that generate the …
Mitochondrial genetic effects on reproductive success: signatures of positive intrasexual, but negative intersexual pleiotropy
Theory predicts that maternal inheritance of mitochondria will facilitate the accumulation of
mtDNA mutations that are male biased, or even sexually antagonistic, in effect. While there …
mtDNA mutations that are male biased, or even sexually antagonistic, in effect. While there …
Buffering of Genetic Regulatory Networks in Drosophila melanogaster
Regulatory variation in gene expression can be described by cis-and trans-genetic
components. Here we used RNA-seq data from a population panel of Drosophila …
components. Here we used RNA-seq data from a population panel of Drosophila …
Sexual Antagonism, Temporally Fluctuating Selection, and Variable Dominance Affect a Regulatory Polymorphism in Drosophila melanogaster
Understanding how genetic variation is maintained within species is a major goal of
evolutionary genetics that can shed light on the preservation of biodiversity. Here, we …
evolutionary genetics that can shed light on the preservation of biodiversity. Here, we …
Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex
Sex differences in gene expression have been widely studied in Drosophila melanogaster.
Sex differences vary across strains, but many molecular studies focus on only a single strain …
Sex differences vary across strains, but many molecular studies focus on only a single strain …
Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster
Environmental changes typically cause rapid gene expression responses in the exposed
organisms, including changes in the representation of gene isoforms with different functions …
organisms, including changes in the representation of gene isoforms with different functions …
Direct testing for allele-specific expression differences between conditions
Allelic imbalance (AI) indicates the presence of functional variation in cis regulatory regions.
Detecting cis regulatory differences using AI is widespread, yet there is no formal statistical …
Detecting cis regulatory differences using AI is widespread, yet there is no formal statistical …
Regulatory Divergence as a Mechanism for X-Autosome Incompatibilities in Caenorhabditis Nematodes
A Viswanath, AD Cutter - Genome Biology and Evolution, 2023 - academic.oup.com
The world's astounding biodiversity results from speciation, the process of formation of
distinct species. Hybrids between species often have reduced fitness due to negative …
distinct species. Hybrids between species often have reduced fitness due to negative …
Event analysis: using transcript events to improve estimates of abundance in RNA-seq data
Alternative splicing leverages genomic content by allowing the synthesis of multiple
transcripts and, by implication, protein isoforms, from a single gene. However, estimating the …
transcripts and, by implication, protein isoforms, from a single gene. However, estimating the …