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Current clinical applications of in vivo gene therapy with AAVs
Hereditary diseases are caused by mutations in genes, and more than 7,000 rare diseases
affect over 30 million Americans. For more than 30 years, hundreds of researchers have …
affect over 30 million Americans. For more than 30 years, hundreds of researchers have …
[HTML][HTML] AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges
L Kang, S **, J Wang, Z Lv, C ** novel therapeutic strategies for Alzheimer's disease
J Cao, J Hou, J **, D Cai - Molecular neurodegeneration, 2018 - Springer
Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …
Design of virus-based nanomaterials for medicine, biotechnology, and energy
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …
Adeno-associated virus-based gene therapy for CNS diseases
Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …
providing a durable therapeutic protein via a single administration. Adeno-associated virus …
Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease
It has been well established that neuronal loss within the cholinergic nucleus basalis of
Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's …
Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's …
Nerve growth factor gene therapy: activation of neuronal responses in Alzheimer disease
Importance Alzheimer disease (AD) is the most common neurodegenerative disorder and
lacks effective disease-modifying therapies. In 2001, we initiated a clinical trial of nerve …
lacks effective disease-modifying therapies. In 2001, we initiated a clinical trial of nerve …