The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …
physiological and pathological events in biology. Metal coordination chemistry, especially …
The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …
Red blood cell and endothelial eNOS independently regulate circulating nitric oxide metabolites and blood pressure
F Leo, T Suvorava, SK Heuser, J Li, A LoBue… - Circulation, 2021 - Am Heart Assoc
Background: Current paradigms suggest that nitric oxide (NO) produced by endothelial cells
(ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary …
(ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary …
Application of methylene blue-vitamin C–N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial
COVID-19 is a global catastrophic event that causes severe acute respiratory syndrome. The
mechanism of the disease remains unclear, and hypoxia is one of the main complications …
mechanism of the disease remains unclear, and hypoxia is one of the main complications …
The role of NO in COVID-19 and potential therapeutic strategies
Nitric oxide (NO) is a free radical playing an important pathophysiological role in
cardiovascular and immune systems. Recent studies reported that NO levels were …
cardiovascular and immune systems. Recent studies reported that NO levels were …
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
The inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show …
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show …
Methods to detect nitric oxide and its metabolites in biological samples
Nitric oxide (NO) methodology is a complex and often confusing science and the focus of
many debates and discussion concerning NO biochemistry. NO is involved in many …
many debates and discussion concerning NO biochemistry. NO is involved in many …
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning
Rationale: Remote ischemic preconditioning (rIPC) with short episodes of
ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to …
ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to …
Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate‐nitrite‐nitric oxide pathway
S Lidder, AJ Webb - British journal of clinical pharmacology, 2013 - Wiley Online Library
The discovery that dietary (inorganic) nitrate has important vascular effects came from the
relatively recent realization of the 'nitrate‐nitrite‐nitric oxide (NO) pathway'. Dietary nitrate …
relatively recent realization of the 'nitrate‐nitrite‐nitric oxide (NO) pathway'. Dietary nitrate …
Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise
Dietary nitrate (NO3−) supplementation with beetroot juice (BR) over 4–6 days has been
shown to reduce the O2 cost of submaximal exercise and to improve exercise tolerance …
shown to reduce the O2 cost of submaximal exercise and to improve exercise tolerance …