Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of
prostaglandins, thromboxane, and levuloglandins. The prostaglandins are autocoid …

Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue
endometriosis play critical physiologic roles. We found that mRNA and protein levels of …

The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) is selectively expressed
in aldosterone target tissues, where it confers aldosterone selectivity for the …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Long-range interactions between distant regulatory elements, such as enhancers, and their
target genes underlie the specificity of gene expression in many developmentally regulated …

Context: Endometriosis is an estrogen-dependent disease. Steroidogenic factor-1 (SF-1), a
transcriptional factor essential for activation of multiple steroidogenic genes for estrogen …

Aberrant gene silencing in mammalian cells is associated with promoter region methylation,
but the sequence of these two events is not clear. This review will consider the possibility …

Gastric cancer is one of the leading causes of cancer death worldwide. Because of its
heterogeneity, gastric cancer has been an interesting model for studying carcinogenesis …

Prostaglandin (PG) E2 is a bioactive eicosanoid that regulates many biologically important
processes in part due to its ability to signal through four distinct G-protein–coupled receptors …