Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …

The aim of this study was to investigate the use of liquisolid technique in improving the
dissolution profiles of naproxen in a solid dosage form. This study was designed to evaluate …

Cyclodextrins (CDs) are cyclic oligosaccharides composed of D-glucopyranoside units
linked by glycosidic bonds. Their main property is the ability to modify the physicochemical …

Solid dispersion systems are widely investigated for the dissolution enhancement of poorly
water soluble drugs. Nevertheless, very limited commercial use has been achieved due to …

Among the different techniques proposed for preparing cyclodextrin inclusion complex in the
solid state, mechanochemical activation by grinding appears as a fast, highly efficient …

The poor water solubility of drugs is major problem for drug formulation. To date, nanoscale
systems for drug delivery have gained much interest as a way to improve the solubility …

Co-amorphous drug amino acid mixtures were previously shown to be a promising
approach to create physically stable amorphous systems with the improved dissolution …

Naproxen (NAP) is a nonsteroidal anti-inflammatory drug. The aim of this work is to enhance
the aqueous solubility and dissolution rate of naproxen (NAP) by forming an inclusion …

The objective of the present study was to formulate naproxen–eudragit® RS100
nanoparticles and investigate the physicochemical characteristics of the prepared …