A healthy brain requires balancing of waking and slee** states. The normal changes in
waking and slee** states result in neurophysiological conditions that either increase or …

Despite advances in understanding the cellular and molecular processes underlying
memory and cognition, and recent successful modulation of cognitive performance in brain …

Brain stimulation has emerged as an effective treatment for a wide range of neurological and
psychiatric diseases. Parkinson's disease, epilepsy, and essential tremor have FDA …

Understanding seizure formation and spread remains a critical goal of epilepsy research.
We used fast in vivo two-photon calcium imaging in male mouse neocortex to reconstruct …

Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …

Intracranial electrophysiological recording in patients with refractory focal epilepsy is the
gold standard for defining epileptogenic tissue. Although the concordance of intracranial …

In animal studies, both seizures and interictal spikes induce synaptic potentiation. Recent
evidence suggests that electroencephalogram slow wave activity during sleep reflects …

Epilepsy is one of the most common neurological disorders, and it affects almost 1% of the
population worldwide. Many people living with epilepsy continue to have seizures despite …

Early implantable epilepsy therapy devices provided open-loop electrical stimulation without
brain sensing, computing, or an interface for synchronized behavioural inputs from patients …

Objective. Electrical deep brain stimulation (DBS) is an established treatment for patients
with drug-resistant epilepsy. Sleep disorders are common in people with epilepsy, and DBS …