Background Neuroimaging studies help us better understand the pathophysiology and
symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging …

Objectives: We performed a systematic review to assess alterations in measures of diffusion
tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in …

One objective of modern neuroimaging is to identify markers that can aid in diagnosis,
disease progression monitoring and long-term drug impact analysis. In this study, Parkinson …

Background: In the midbrain of patients with Parkinson disease (PD), there is a selective
loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (SN). In a …

Conventional single tensor diffusion analysis models have provided mixed findings in the
substantia nigra of Parkinson's disease, but recent work using a bi-tensor analysis model …

Purpose: To determine if tissue magnetic susceptibility is a more direct marker of tissue iron
content than other MR markers of iron. This study presents the first quantitative, in vivo …

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) offers a unique window on
the connectivity changes, extending beyond the basal ganglia, which accompany the …

Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra
of Parkinson's disease. It is the case, however, that partial volume effects from free water can …

To date, the most frequently used Parkinson's disease (PD) biomarkers are the brain
imaging measures of dopaminergic dysfunction using positron emission tomography and …

This study tested the hypothesis that diffusion tensor imaging can detect alteration in
microscopic integrity of white matter and basal ganglia regions known to be involved in …