Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Abstract The Wellcome Trust Sanger Institute is one of the world's largest genome centers,
and a substantial amount of our sequencing is performed with'next-generation'massively …

INTRODUCTION The study of hominin history has progressed through both archaeological
and genetic insights. Although DNA sequencing from hominin skeletal remains allows the …

We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of
Europe and western Asia before disappearing 30,000 years ago. We present a draft …

The large amount of DNA sequence data generated by high-throughput sequencing
technologies often allows multiple samples to be sequenced in parallel on a single …

DNA library preparation for high-throughput sequencing of genomic DNA usually involves
ligation of adapters to double-stranded DNA fragments. However, for highly degraded DNA …

The geographic and temporal origins of the domestic dog remain controversial, as genetic
data suggest a domestication process in East Asia beginning 15,000 years ago, whereas …

Summary Ludwig van Beethoven (1770–1827) remains among the most influential and
popular classical music composers. Health problems significantly impacted his career as a …

OBJECTIVE: We sought to evaluate a multiplexed massively parallel shotgun sequencing
assay for noninvasive trisomy 21 detection using circulating cell-free fetal DNA. STUDY …