Outer membrane biogenesis

A Konovalova, DE Kahne… - Annual review of …, 2017 - annualreviews.org
The hallmark of gram-negative bacteria and organelles such as mitochondria and
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …

Outer membrane protein biogenesis in Gram-negative bacteria

SE Rollauer, MA Sooreshjani… - … Transactions of the …, 2015 - royalsocietypublishing.org
Gram-negative bacteria contain a double membrane which serves for both protection and for
providing nutrients for viability. The outermost of these membranes is called the outer …

Structural basis of outer membrane protein insertion by the BAM complex

Y Gu, H Li, H Dong, Y Zeng, Z Zhang, NG Paterson… - Nature, 2016 - nature.com
All Gram-negative bacteria, mitochondria and chloroplasts have outer membrane proteins
(OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative …

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria

JE Horne, DJ Brockwell, SE Radford - Journal of Biological Chemistry, 2020 - ASBMB
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

The structure of the β-barrel assembly machinery complex

J Bakelar, SK Buchanan, N Noinaj - Science, 2016 - science.org
β-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-
negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200 …

The β-barrel assembly machinery in motion

N Noinaj, JC Gumbart, SK Buchanan - Nature Reviews Microbiology, 2017 - nature.com
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …

The assembly of β-barrel outer membrane proteins

D Tomasek, D Kahne - Current opinion in microbiology, 2021 - Elsevier
Highlights•The BamA β-barrel adopts an open state with its first and last β-strands
unpaired.•BamA β-strand 1 captures the C-terminal β-strand of substrates by hydrogen …

Membrane protein insertion through a mitochondrial β-barrel gate

AIC Höhr, C Lindau, C Wirth, J Qiu, DA Stroud, S Kutik… - Science, 2018 - science.org
INTRODUCTION The outer membranes of Gram-negative bacteria, mitochondria, and
chloroplasts characteristically contain β-barrel membrane proteins. These proteins contain …

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

L Han, J Zheng, Y Wang, X Yang, Y Liu… - Nature structural & …, 2016 - nature.com
In Gram-negative bacteria, the assembly of β-barrel outer-membrane proteins (OMPs)
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …

Countering gram-negative antibiotic resistance: Recent progress in disrupting the outer membrane with novel therapeutics

KM Lehman, M Grabowicz - Antibiotics, 2019 - mdpi.com
Gram-negative bacteria shield themselves from antibiotics by producing an outer membrane
(OM) that forms a formidable permeability barrier. Multidrug resistance among these …