Ovarian cancer is the deadliest gynecological cancer, leading to over 152,000 deaths each
year. A late diagnosis is the primary factor causing a poor prognosis of ovarian cancer and …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

We have performed an in-depth single-cell phenotypic characterization of high-grade serous
ovarian cancer (HGSOC) by multiparametric mass cytometry (CyTOF). Using a CyTOF …

Breast cancer is the second leading cause of cancer death in women. Serum biomarkers
such as cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125), and carcinoembryonic …

HE4, also known as WFDC2, is a useful biomarker for ovarian cancer when either used
alone or in combination with CA125. HE4 is also overexpressed in endometrial cancer (EC) …

Ovarian masses, a common finding among pre-and post-menopausal women, can be
benign or malignant. Ovarian cancer is the leading cause of death from gynecologic …

Background Amongst the newly proposed biomarkers for ovarian cancer, serum human
epididymis protein 4 (HE4) shows the greatest potential for clinical use. However, systematic …

Background Measurement of human epididymis protein 4 (HE4) in serum has recently been
proposed for clinical use in the framework of ovarian cancer (OvCa). We sought to retrace …

Lung cancer (LC) is the most frequently diagnosed cancer and is the leading cause of
cancer-associated death. Serum markers that exhibit high sensitivity and specificity for LC …

A fluorescence quenching enhanced immunoassay has been developed to achieve
ultrasensitive recognition of human epididymal 4 (HE4) modifying the fluorescence …