Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

The endothelium, a tissue that forms a single layer of cells lining various organs and cavities
of the body, especially the heart and blood as well as lymphatic vessels, plays a complex …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Reactive oxygen species (ROS) serve as cell signaling molecules for normal biologic
processes. However, the generation of ROS can also provoke damage to multiple cellular …

NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …

The threat of radiation-induced late normal tissue injury limits the dose of radiation that can
be delivered safely to cancer patients presenting with solid tumors. Tissue dysfunction and …

Purpose: To review the data concerning the role of endogenously generated reactive
oxygen species (ROS) in the non-targeted ionizing radiation (IR) effects and in …

Ionizing radiation (IR) and/or chemotherapy causes not only acute tissue damage but also
late effects including long-term (or residual) bone marrow (BM) injury. The induction of …

Background: Nowadays, ionizing radiations are used for various medical and terroristic
aims. These purposes involve exposure to ionizing radiations. Hence, people are at risk for …