The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year
survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a …

With the rapid development of three-dimensional (3D) bioprinting technology, the research
revolving around in vitro functional pancreas and tumor models has become the focus of …

Ferroptosis is an iron-dependent regulated form of cell death caused by excessive lipid
peroxidation. This form of cell death differed from known forms of cell death in morphological …

Aims: Ferroptosis, a type of oxidative cell death driven by unlimited lipid peroxidation, is
emerging as a target for cancer therapy. Although mitochondrial dysfunction may lead to …

The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

Pancreatic cancer is the third most common cause of cancer-related deaths in the United
States. Although gemcitabine is the standard of care for most patients with pancreatic …

Pancreatic adenocarcinoma (PDAC) is predicted to become the second leading cause of
cancer deaths by 2030 and this is mostly due to therapy failure. Limited treatment options …