Potent acetylcholinesterase inhibitors: potential drugs for Alzheimer's disease

H Akıncıoğlu, İ Gülçin - Mini reviews in medicinal chemistry, 2020 - benthamdirect.com
Alzheimer's disease (AD) is one of the cognitive or memory-related impairments occurring
with advancing age. Since its exact mechanism is not known, the full therapy has still not …

[HTML][HTML] Anticholinergic and antioxidant activities of usnic acid-an activity-structure insight

KC Cakmak, İ Gülçin - Toxicology reports, 2019 - Elsevier
Usnic acid, as active dibenzofuran derivative, isolated and characterized from some lichen
species. The aim of manuscript was to evaluate antioxidant, anticholinergic and antidiabetic …

Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors

F Turkan, A Cetin, P Taslimi, M Karaman, İ Gulçin - Bioorganic chemistry, 2019 - Elsevier
A series of substituted pyrazole compounds (1–8 and 9a, b) were synthesized and their
structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole …

Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS

I Gulcin, R Kaya, AC Goren, H Akincioglu… - … Journal of Food …, 2019 - Taylor & Francis
Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were
evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant …

A biochemistry‐oriented drug design: synthesis, anticancer activity, enzymes inhibition, molecular docking studies of novel 1, 2, 4-triazole derivatives

K Yuriy, G Kusdemir, P Volodymyr… - Journal of …, 2024 - Taylor & Francis
In this study, we researched the reactions of 5-(5-bromofuran-2-yl)-4-methyl-1, 2, 4-triazole-3-
thiol and 5-thiophene-(3-ylmethyl)-4R-1, 2, 4-triazole-3-thiols with some halogen-containing …

Novel 2-aminopyridine liganded Pd (II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and bioactivity properties

F Erdemir, DB Celepci, A Aktaş, Y Gök, R Kaya… - Bioorganic …, 2019 - Elsevier
In this work, the synthesis, crystal structure, characterization, and enzyme inhibition effects of
the novel a series of 2-aminopyridine liganded Pd (II) N-heterocyclic carbene (NHC) …

Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors

S Burmaoglu, AO Yilmaz, MF Polat, R Kaya, İ Gulcin… - Bioorganic …, 2019 - Elsevier
A novel class of fluoro-substituted tris-chalcones derivatives (5a-5i) was synthesized from
phloroglucinol and corresponding benzaldehydes. A three step synthesis method was …

Anticholinergic, antidiabetic and antioxidant activities of Anatolian pennyroyal (Mentha pulegium)-analysis of its polyphenol contents by LC-MS/MS

İ Gülçin, AC Gören, P Taslimi, SH Alwasel… - Biocatalysis and …, 2020 - Elsevier
Methanol and water extracts of pennyroyal (Mentha pulegium) were evaluated for their
antioxidant profiles by eight distinguished bioanalytical methods and for their inhibitory …

Therapeutic potential of multifunctional derivatives of cholinesterase inhibitors

M Przybyłowska, K Dzierzbicka… - Current …, 2021 - benthamdirect.com
The aim of this work is to review tacrine analogues from the last three years, which were not
included in the latest review work, donepezil and galantamine hybrids from 2015 and …

Sage (Salvia pilifera): determination of its polyphenol contents, anticholinergic, antidiabetic and antioxidant activities

İ Gülçin, AZ Tel, AC Gören, P Taslimi… - Journal of food …, 2019 - Springer
In this work, we determined for the first time the Salvia pilifera Montbret & Aucher ex
Bentham as an important source for natural products with antioxidant and antidiabetic …