Natural antioxidant compounds as potential pharmaceutical tools against neurodegenerative diseases

A Marino, M Battaglini, N Moles, G Ciofani - ACS omega, 2022 - ACS Publications
Natural antioxidants are a very large diversified family of molecules classified by activity
(enzymatic or nonenzymatic), chemical-physical properties (eg, hydrophilic or lipophilic) …

Adult health and transition stage-specific rotenone-mediated Drosophila model of Parkinson's disease: Impact on late-onset neurodegenerative disease models

M Ayajuddin, L Phom, Z Koza, P Modi, A Das… - Frontiers in molecular …, 2022 - frontiersin.org
Parkinson's disease (PD) affects almost 1% of the population worldwide over the age of 50
years. Exposure to environmental toxins like paraquat and rotenone is a risk factor for …

Changes in heme oxygenase level during development affect the adult life of Drosophila melanogaster

B Bilska, M Damulewicz, TAL Abaquita… - Frontiers in Cellular …, 2023 - frontiersin.org
Heme oxygenase (HO) has been shown to control various cellular processes in both
mammals and Drosophila melanogaster. Here, we investigated how changes in HO levels in …

Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: a possible link with Parkinson's disease

A Abbaoui, H Chatoui, O El Hiba, H Gamrani - Neuroscience letters, 2017 - Elsevier
Numerous findings indicate an involvement of heavy metals in the neuropathology of
several neurodegenerative disorders, especially Parkinson's disease (PD). Previous studies …

The dual role of heme oxygenase in regulating apoptosis in the nervous system of Drosophila melanogaster

TAL Abaquita, M Damulewicz, G Tylko… - Frontiers in Physiology, 2023 - frontiersin.org
Accumulating evidence from mammalian studies suggests the dual-faced character of heme
oxygenase (HO) in oxidative stress-dependent neurodegeneration. The present study aimed …

Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP70/83

MA Saraiva, E da Rosa Ávila… - Oxidative Medicine …, 2018 - Wiley Online Library
Mancozeb (MZ), a manganese‐and zinc‐containing ethylene‐bis‐dithiocarbamate, is a
broad‐spectrum fungicide. Harmful effects of this fungicide have been reported in nontarget …

[HTML][HTML] Regulation of heme oxygenase and its cross-talks with apoptosis and autophagy under different conditions in Drosophila

AL Abaquita, M Damulewicz, D Bhattacharya, E Pyza - Antioxidants, 2021 - mdpi.com
Antioxidants | Free Full-Text | Regulation of Heme Oxygenase and Its Cross-Talks with Apoptosis
and Autophagy under Different Conditions in Drosophila Next Article in Journal Peucedanum …

Inhibiting thrombin improves motor function and decreases oxidative stress in the LRRK2 transgenic Drosophila melanogaster model of Parkinson's disease

SL Johnson, J Iannucci, NP Seeram… - … and Biophysical Research …, 2020 - Elsevier
Parkinson's disease (PD) is a complex neurodegenerative disease characterized by the
presence of tremors, loss of dopaminergic neurons and accumulation of α-synuclein. While …

[HTML][HTML] A Simple Immunofluorescence Method to Characterize Neurodegeneration and Tyrosine Hydroxylase Reduction in Whole Brain of a Drosophila Model of …

R Chaurasia, M Ayajuddin, GS Ratnaparkhi… - Bio …, 2024 - ncbi.nlm.nih.gov
Dopaminergic (DAergic) neurodegeneration in the substantia nigra pars compacta of the
human brain is the pathological feature associated with Parkinson's disease (PD) …

Regulation of Heme Oxygenase and Its Cross-Talks with Apoptosis and Autophagy under Different Conditions in Drosophila

T Al L. Abaquita, M Damulewicz, D Bhattacharya… - Antioxidants, 2021 - mdpi.com
Heme oxygenase (HO) is one of the cytoprotective enzymes that can mitigate the effects of
oxidative stress. Here, we found that the ho mRNA level oscillates in the brain of Drosophila …