Small RNA-based antimicrobial immunity
Protection against microbial infection in eukaryotes is provided by diverse cellular and
molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus …
molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus …
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design
O Terenius, A Papanicolaou, JS Garbutt… - Journal of insect …, 2011 - Elsevier
Gene silencing through RNA interference (RNAi) has revolutionized the study of gene
function, particularly in non-model insects. However, in Lepidoptera (moths and butterflies) …
function, particularly in non-model insects. However, in Lepidoptera (moths and butterflies) …
RNA-based antiviral immunity
SW Ding - Nature Reviews Immunology, 2010 - nature.com
In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a
pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) …
pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) …
Thirty years of baculovirus–insect cell protein expression: from dark horse to mainstream technology
MM Van Oers, GP Pijlman… - Journal of General …, 2015 - microbiologyresearch.org
In December 1983, a seminal paper appeared on the overexpression of human IFN-β in
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …
RNA interference in insects: protecting beneficials and controlling pests
E Vogel, D Santos, L Mingels, TW Verdonckt… - Frontiers in …, 2019 - frontiersin.org
Insects constitute the largest and most diverse group of animals on Earth with an equally
diverse virome. The main antiviral immune system of these animals is the post …
diverse virome. The main antiviral immune system of these animals is the post …
The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster
CL Webster, FM Waldron, S Robertson, D Crowson… - PLoS …, 2015 - journals.plos.org
Drosophila melanogaster is a valuable invertebrate model for viral infection and antiviral
immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic …
immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic …
The role of viruses in identifying and analyzing RNA silencing
DC Baulcombe - Annual Review of Virology, 2022 - annualreviews.org
Adaptive antiviral immunity in plants is an RNA-based mechanism in which small RNAs
derived from both strands of the viral RNA are guides for an Argonaute (AGO) nuclease. The …
derived from both strands of the viral RNA are guides for an Argonaute (AGO) nuclease. The …
RNA interference functions as an antiviral immunity mechanism in mammals
Diverse eukaryotic hosts produce virus-derived small interfering RNAs (siRNAs) to direct
antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the …
antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the …
VirusDetect: An automated pipeline for efficient virus discovery using deep sequencing of small RNAs
Accurate detection of viruses in plants and animals is critical for agriculture production and
human health. Deep sequencing and assembly of virus-derived small interfering RNAs has …
human health. Deep sequencing and assembly of virus-derived small interfering RNAs has …
Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans
Induced expression of the Flock House virus in the soma of C. elegans results in the RNAi-
dependent production of virus-derived, small-interfering RNAs (viRNAs), which in turn …
dependent production of virus-derived, small-interfering RNAs (viRNAs), which in turn …