Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

E Barati, H Nikzad, M Karimian - Cellular and Molecular Life Sciences, 2020 - Springer
Infertility is a global health problem involving about 15% of couples. Approximately half of
the infertility cases are related to male factors. The oxidative stress, which refers to an …

[HTML][HTML] Impact of oxidative stress on male and female germ cells: implications for fertility

RJ Aitken - Reproduction, 2020 - rep.bioscientifica.com
Male and female germ lines are vulnerable to oxidative stress. In spermatozoa, such stress
triggers a lipid peroxidation cascade that culminates in the generation of electrophilic lipid …

Efficient near infrared light triggered nitric oxide release nanocomposites for sensitizing mild photothermal therapy

X Zhang, J Du, Z Guo, J Yu, Q Gao, W Yin… - Advanced …, 2019 - Wiley Online Library
Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big
challenges of limited therapeutic accuracy and side‐effects due to uneven heat distribution …

Causes, effects and molecular mechanisms of testicular heat stress

D Durairajanayagam, A Agarwal, C Ong - Reproductive biomedicine online, 2015 - Elsevier
The process of spermatogenesis is temperature-dependent and occurs optimally at
temperatures slightly lower than that of the body. Adequate thermoregulation is imperative to …

Autophagy: a multifaceted player in the fate of sperm

M Wang, L Zeng, P Su, L Ma, M Zhang… - Human Reproduction …, 2022 - academic.oup.com
BACKGROUND Autophagy is an intracellular catabolic process of degrading and recycling
proteins and organelles to modulate various physiological and pathological events …

[HTML][HTML] Polystyrene microplastics induce mitochondrial damage in mouse GC-2 cells

T Liu, B Hou, Z Wang, Y Yang - Ecotoxicology and Environmental Safety, 2022 - Elsevier
Microplastics are widely distributed, such as oceans, rivers and the atmosphere, with many
opportunities for human exposure and potential health risks. Polystyrene microplastic (PS …

[HTML][HTML] Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis

P Sharma, N Kaushal, LR Saleth, S Ghavami… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

Heat shock response and autophagy—cooperation and control

K Dokladny, OB Myers, PL Moseley - Autophagy, 2015 - Taylor & Francis
Protein quality control (proteostasis) depends on constant protein degradation and
resynthesis, and is essential for proper homeostasis in systems from single cells to whole …

Diet-induced obesity impairs spermatogenesis: A potential role for autophagy

Y Mu, W Yan, T Yin, Y Zhang, J Li, J Yang - Scientific reports, 2017 - nature.com
Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a
series of cellular functions. It has been found that autophagy is closely involved in the …

Mechanism of inflammatory associated impairment of sperm function, spermatogenesis and steroidogenesis

H Hasan, S Bhushan, M Fijak… - Frontiers in Endocrinology, 2022 - frontiersin.org
Infection and inflammation are relevant entities of male reproductive disorders that can lead
to sub-/infertility. Associated damage of the testis of affected men and in rodent models …