3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-
stage embryos, have emerged as a powerful tool to study the early stages of mammalian …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Gastrulation is a fundamental and critical process of animal development whereby the mass
of cells that results from the proliferation of the zygote transforms itself into a recognizable …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

The use of stem cells to model the early human embryo promises to transform our
understanding of developmental biology and human reproduction. In this review, we present …

Multicellular organisms of various complexities self-organize in nature. Organoids are in
vitro 3D structures that display important aspects of the anatomy and physiology of their in …

The mesodermal precursor populations for different internal organ systems are specified
during gastrulation by the combined activity of extracellular signaling systems such as BMP …

Normal developmental progression relies on close interactions between the embryonic and
extraembryonic lineages in the pre-and peri-gastrulation stage conceptus. For example …

The maintenance of multi-cellular developed tissue depends on the proper cell production
rate to replace the cells destroyed by the programmed process of cell death. The stem cell is …