The carboxylic acid functional group can be an important constituent of a pharmacophore,
however, the presence of this moiety can also be responsible for significant drawbacks …

This short review compiles the main results of the studies in tetrazole chemistry published in
the period 2009–2016. Attention is directed to the structure, reactivity, synthetic problems …

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a
classical strategy in medicinal chemistry. The general underlying principle is that by …

The tetrazole ring is an important pharmacophore. It is a structural component in many
drugs, drug candidates (or lead compounds) and various biochemical reagents. This review …

Tetrazole cycle is a promising pharmacophore fragment frequently used in the development
of novel drugs. This moiety is a stable, practically non-metabolized bioisosteric analog of …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

Corrosion is one of the problems that most industries face. Our aim in the current study is to
perform density functional theory calculations and Monte Carlo simulation to theoretically …

The heterocycle ring tetrazole is an important moiety relevant to medicinal chemistry since it
is present in some drugs with clinical importance. Its primary biological activity is being a …

The hydrogen-bonding activation for 66 organocatalysts has been quantified using a 31P
NMR binding experiment with triethylphosphine oxide (TEPO). Diverse structural classes …

Intermolecular interactions of organic, inorganic, and organometallic compounds are the key
to many composition–structure and structure–property networks. In this review, some of …