Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

The production of natural antibiotic peptides has emerged as an important mechanism of
innate immunity in plants and animals. Defensins are diverse members of a large family of …

Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli,
Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse …

Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring
molecules that are produced as a first line of defense by all multicellular organisms. These …

Cysteine-rich antimicrobial peptides are abundant in animal and plant tissues involved in
host defense. In insects, most are synthesized in the fat body, an organ analogous to the …

The concept of innate immunity refers to the first-line host defense that serves to limit
infection in the early hours after exposure to microorganisms. Recent data have highlighted …

The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

The growing public health problem of infections caused by multiresistant Gram-positive
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …

Defensins are peptidic components of the innate immune system of plants and animals. In
mammals, defensins have evolved to have a central function in the host defense properties …

Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides
when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs …