Identification, evaluation, and management of children with autism spectrum disorder
SL Hyman, SE Levy, SM Myers, DZ Kuo, S Apkon… - …, 2020 - publications.aap.org
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with reported
prevalence in the United States of 1 in 59 children (approximately 1.7%). Core deficits are …
prevalence in the United States of 1 in 59 children (approximately 1.7%). Core deficits are …
From the genetic architecture to synaptic plasticity in autism spectrum disorder
T Bourgeron - Nature Reviews Neuroscience, 2015 - nature.com
Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …
[HTML][HTML] Disruptive CHD8 mutations define a subtype of autism early in development
Autism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …
FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders
Autism spectrum disorder (ASD) is a disorder of brain development. Most cases lack a clear
etiology or genetic basis, and the difficulty of re-enacting human brain development has …
etiology or genetic basis, and the difficulty of re-enacting human brain development has …
CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS …
P Wang, R Mokhtari, E Pedrosa, M Kirschenbaum… - Molecular autism, 2017 - Springer
Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …
Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci
Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC)(N=
2,591 families) replicates prior findings of strong association with autism spectrum disorders …
2,591 families) replicates prior findings of strong association with autism spectrum disorders …
Head circumference and brain size in autism spectrum disorder: A systematic review and meta-analysis
R Sacco, S Gabriele, AM Persico - Psychiatry Research: Neuroimaging, 2015 - Elsevier
Macrocephaly and brain overgrowth have been associated with autism spectrum disorder.
We performed a systematic review and meta-analysis to provide an overall estimate of effect …
We performed a systematic review and meta-analysis to provide an overall estimate of effect …
The neuroanatomy of autism spectrum disorder: An overview of structural neuroimaging findings and their translatability to the clinical setting
C Ecker - Autism, 2017 - journals.sagepub.com
Autism spectrum disorder is a complex neurodevelopmental disorder, which is accompanied
by differences in brain anatomy, functioning and brain connectivity. Due to its …
by differences in brain anatomy, functioning and brain connectivity. Due to its …
Human induced pluripotent stem cells for modelling neurodevelopmental disorders
We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …
disorders, owing to the fact that postmortem and imaging studies can only measure the …
ASD validity
L Waterhouse, E London, C Gillberg - Review Journal of Autism and …, 2016 - Springer
ASD research is at an important crossroads. The ASD diagnosis is important for assigning a
child to early behavioral intervention and explaining a child's condition. But ASD research …
child to early behavioral intervention and explaining a child's condition. But ASD research …