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Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application
S Wang, XH Yuan, SQ Wang, W Zhao, XB Chen… - European Journal of …, 2021 - Elsevier
Considerable progress has been made in the development of anticancer agents over the
past few decades, and a lot of new anticancer agents from natural and synthetic sources …
past few decades, and a lot of new anticancer agents from natural and synthetic sources …
Azaindole derivatives as potential kinase inhibitors and their SARs elucidation
G Fang, H Chen, Z Cheng, Z Tang, Y Wan - European Journal of Medicinal …, 2023 - Elsevier
Currently, heterocycles have occupied an important position in the fields of drug design.
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …
The role of the food matrix and gastrointestinal tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and …
Many foods contain appreciable levels of engineered nanomaterials (ENMs)(diameter< 100
nm) that may be either intentionally or unintentionally added. These ENMs vary considerably …
nm) that may be either intentionally or unintentionally added. These ENMs vary considerably …
[HTML][HTML] Structure-based molecular modeling in SAR analysis and lead optimization
V Temml, Z Kutil - Computational and structural biotechnology journal, 2021 - Elsevier
In silico methods like molecular docking and pharmacophore modeling are established
strategies in lead identification. Their successful application for finding new active molecules …
strategies in lead identification. Their successful application for finding new active molecules …
Anticancer Potential of the S‐Heterocyclic Ring Containing Drugs and its Bioactivation to Reactive Metabolites
S Maji, B Debnath, S Panda, T Manna… - Chemistry & …, 2024 - Wiley Online Library
Sulfur‐containing heterocyclic derivatives have been disclosed for binding with a wide
range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing …
range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing …
Rhodium (III) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies
Two rhodium complexes Rh1 and Rh2 with isoquinoline derivatives were synthesized and
characterized. Both complexes displayed strong anticancer activity against various cancer …
characterized. Both complexes displayed strong anticancer activity against various cancer …
[HTML][HTML] Toxicodynamics of mycotoxins in the framework of food risk assessment—an in silico perspective
Mycotoxins severely threaten the health of humans and animals. For this reason, many
countries have enforced regulations and recommendations to reduce the dietary exposure …
countries have enforced regulations and recommendations to reduce the dietary exposure …
Recent developments in mitogen activated protein kinase inhibitors as potential anticancer agents
The mitogen activated protein kinase (MAPK) belongs to group of kinase that links the
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
Modeling the DFT structural and reactivity studies of a pyrimidine-6-carboxylate derivative with reference to its wavefunction-dependent, MD simulations and …
M Smitha, YS Mary, YS Mary, G Serdaroglu… - Journal of Molecular …, 2021 - Elsevier
Spectroscopic, electronic and chemical properties and molecular docking simulations of
ethyl-2-(4-ethoxybenzylidene)-7-methyl-3-oxo-5-(4-benzyloxyphenyl)-2, 3-dihydro-5H-[1, 3] …
ethyl-2-(4-ethoxybenzylidene)-7-methyl-3-oxo-5-(4-benzyloxyphenyl)-2, 3-dihydro-5H-[1, 3] …