Thiazole-containing compounds as therapeutic targets for cancer therapy

PC Sharma, KK Bansal, A Sharma, D Sharma… - European journal of …, 2020 - Elsevier
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application

S Wang, XH Yuan, SQ Wang, W Zhao, XB Chen… - European Journal of …, 2021 - Elsevier
Considerable progress has been made in the development of anticancer agents over the
past few decades, and a lot of new anticancer agents from natural and synthetic sources …

Azaindole derivatives as potential kinase inhibitors and their SARs elucidation

G Fang, H Chen, Z Cheng, Z Tang, Y Wan - European Journal of Medicinal …, 2023 - Elsevier
Currently, heterocycles have occupied an important position in the fields of drug design.
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …

The role of the food matrix and gastrointestinal tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and …

DJ McClements, G DeLoid, G Pyrgiotakis, JA Shatkin… - NanoImpact, 2016 - Elsevier
Many foods contain appreciable levels of engineered nanomaterials (ENMs)(diameter< 100
nm) that may be either intentionally or unintentionally added. These ENMs vary considerably …

[HTML][HTML] Structure-based molecular modeling in SAR analysis and lead optimization

V Temml, Z Kutil - Computational and structural biotechnology journal, 2021 - Elsevier
In silico methods like molecular docking and pharmacophore modeling are established
strategies in lead identification. Their successful application for finding new active molecules …

Anticancer Potential of the S‐Heterocyclic Ring Containing Drugs and its Bioactivation to Reactive Metabolites

S Maji, B Debnath, S Panda, T Manna… - Chemistry & …, 2024 - Wiley Online Library
Sulfur‐containing heterocyclic derivatives have been disclosed for binding with a wide
range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing …

Rhodium (III) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies

TM Khan, NS Gul, X Lu, R Kumar, MI Choudhary… - Dalton …, 2019 - pubs.rsc.org
Two rhodium complexes Rh1 and Rh2 with isoquinoline derivatives were synthesized and
characterized. Both complexes displayed strong anticancer activity against various cancer …

[HTML][HTML] Toxicodynamics of mycotoxins in the framework of food risk assessment—an in silico perspective

L Dellafiora, C Dall'Asta, G Galaverna - Toxins, 2018 - mdpi.com
Mycotoxins severely threaten the health of humans and animals. For this reason, many
countries have enforced regulations and recommendations to reduce the dietary exposure …

Recent developments in mitogen activated protein kinase inhibitors as potential anticancer agents

VJ Singh, B Sharma, PA Chawla - Bioorganic Chemistry, 2021 - Elsevier
The mitogen activated protein kinase (MAPK) belongs to group of kinase that links the
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …

Modeling the DFT structural and reactivity studies of a pyrimidine-6-carboxylate derivative with reference to its wavefunction-dependent, MD simulations and …

M Smitha, YS Mary, YS Mary, G Serdaroglu… - Journal of Molecular …, 2021 - Elsevier
Spectroscopic, electronic and chemical properties and molecular docking simulations of
ethyl-2-(4-ethoxybenzylidene)-7-methyl-3-oxo-5-(4-benzyloxyphenyl)-2, 3-dihydro-5H-[1, 3] …