Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted
drugs, which has been a significant challenge in cancer management. With the growing …

Cancer is one of the leading causes of death and significantly burdens the healthcare
system. Due to its prevalence, there is undoubtedly an unmet need to discover novel …

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch
signaling pathway is one of the most commonly activated signaling pathways in cancer …

In spite of billions of dollars expended on cancer research every year, the incidence rate and
the mortality rate due to this widespread disease has increased drastically over the last few …

Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is
largely caused by a variety of gene mutations. There are continuous efforts being made to …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Despite incessant research, colon cancer still is one of the most common causes of fatalities
in both men and women worldwide. Also, nearly 50% of patients with colorectal cancer show …

High recurrence and metastasis rates and poor prognoses are the major challenges of
current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an …

Abstract Background Cancer stem cells (CSCs) are strongly associated with high
tumourigenicity, chemotherapy or radiotherapy resistance, and metastasis and recurrence …

The Notch family consists of four highly conserved transmembrane receptors. The release of
the active intracellular domain requires the enzymatic activity of γ-secretase. Notch is …