Intricacies of TGF-β signaling in Treg and Th17 cell biology

J Wang, X Zhao, YY Wan - Cellular & molecular immunology, 2023 - nature.com
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal Transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Dietary ellagic acid therapy for CNS autoimmunity: Targeting on Alloprevotella rava and propionate metabolism

B Han, L Shi, MY Bao, FL Yu, Y Zhang, XY Lu, Y Wang… - Microbiome, 2024 - Springer
Background Mediterranean diet rich in polyphenolic compounds holds great promise to
prevent and alleviate multiple sclerosis (MS), a central nervous system autoimmune disease …

Interleukin 23 receptor: Expression and regulation in immune cells

I Mezghiche, H Yahia‐Cherbal… - European Journal of …, 2024 - Wiley Online Library
The importance of IL‐23 and its specific receptor, IL‐23R, in the pathogenesis of several
chronic inflammatory diseases has been established, but the underlying pathological …

Gut-first Parkinson's disease is encoded by gut dysbiome

MF Munoz-Pinto, E Candeias, I Melo-Marques… - Molecular …, 2024 - Springer
Abstract Background In Parkinson's patients, intestinal dysbiosis can occur years before
clinical diagnosis, implicating the gut and its microbiota in the disease. Recent evidence …

Differential regulation of lineage-determining transcription factor expression in innate lymphoid cell and adaptive T helper cell subsets

D Fang, A Healy, J Zhu - Frontiers in Immunology, 2023 - frontiersin.org
CD4 T helper (Th) cell subsets, including Th1, Th2 and Th17 cells, and their innate
counterparts innate lymphoid cell (ILC) subsets consisting of ILC1s, ILC2s and ILC3s …

Lentinula edodes Cultured Extract and Rouxiella badensis subsp. acadiensis (Canan SV-53) Intake Alleviates Immune Deregulation and Inflammation by …

R Shahbazi, H Yasavoli-Sharahi, N Alsadi… - International Journal of …, 2023 - mdpi.com
Puberty is a critical developmental period of life characterized by marked physiological
changes, including changes in the immune system and gut microbiota development …

[HTML][HTML] Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases

L Lin, R Ren, Q **ong, C Zheng, B Yang, H Wang - Autoimmunity Reviews, 2024 - Elsevier
T cells are key drivers of the pathogenesis of autoimmune diseases by producing cytokines,
stimulating the generation of autoantibodies, and mediating tissue and cell damage. Distinct …

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

M Najar, S Rahmani, WH Faour, SG Alsabri… - Cells, 2024 - mdpi.com
As a form of immunomodulatory therapeutics, mesenchymal stromal/stem cells (MSCs) from
umbilical cord (UC) tissue were assessed for their dynamic interplay with the Th-17 immune …

Delineating the Immunotherapeutic Potential of Vitamin E and Its Analogues in Cancer: A Comprehensive Narrative Review

NR Morgan, P Ramdas… - BioMed Research …, 2024 - Wiley Online Library
Cancer is a disease resulting from uncontrolled cell division, which significantly contributes
to human mortality rates. An alternative approach to cancer treatment, such as cancer …