Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Background Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related
death worldwide with metastases being the main cause of cancer-related death. Here, we …

In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …

Translation initiation in eukaryotes is a highly regulated and complex stage of gene
expression. It requires the action of at least 12 initiation factors, many of which are known to …

Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …

Mitochondria are eukaryotic organelles that generate most of the energy in the cell by
oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a …

The correct translation of mRNA depends critically on the ability to initiate at the right AUG
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Galloway–Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by
the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain …