Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

An overview: the diversified role of mitochondria in cancer metabolism

Y Sun, Y Guo, X Shi, X Chen, W Feng… - … journal of biological …, 2023 - pmc.ncbi.nlm.nih.gov
Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

Caveolin-1 controls mitochondrial damage and ROS production by regulating fission-fusion dynamics and mitophagy

Y Jiang, S Krantz, X Qin, S Li, H Gunasekara, YM Kim… - Redox biology, 2022 - Elsevier
As essential regulators of mitochondrial quality control, mitochondrial dynamics and
mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here …

Biomimetic nanoparticle synchronizing pyroptosis induction and mitophagy inhibition for anti-tumor therapy

Y Deng, F Jia, P Jiang, L Chen, L **ng, X Shen, L Li… - Biomaterials, 2023 - Elsevier
Inducing pyroptosis in cancer cells can result in a strong anti-tumor immune response. Our
preliminary study indicates that pyroptosis can be temporarily strengthened by disrupting …

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

N Wu, W Zheng, Y Zhou, Y Tian, M Tang, X Feng… - Ageing Research …, 2024 - Elsevier
Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis

M Liu, Y Fan, D Li, B Han, Y Meng, F Chen… - Molecular …, 2021 - Wiley Online Library
Despite recent progress in non‐small‐cell lung cancer (NSCLC) treatment, treatment
outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a …

Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics

SR Mishra, KK Mahapatra, BP Behera, S Patra… - … International Journal of …, 2021 - Elsevier
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the
sensation of various pathogenic and non-pathogenic damage signals and has a vital role in …

Mitochondria in cancer stem cells: Achilles heel or hard armor

X Zheng, J Chen, Y Sun, T Chen, J Wang, S Yu - Trends in Cell Biology, 2023 - cell.com
Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …