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Mito‐bomb: targeting mitochondria for cancer therapy
X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …
An overview: the diversified role of mitochondria in cancer metabolism
Y Sun, Y Guo, X Shi, X Chen, W Feng… - … journal of biological …, 2023 - pmc.ncbi.nlm.nih.gov
Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …
Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …
therapy has received significant attention since the inception, due to its ability to efficiently …
Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives
J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …
Caveolin-1 controls mitochondrial damage and ROS production by regulating fission-fusion dynamics and mitophagy
As essential regulators of mitochondrial quality control, mitochondrial dynamics and
mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here …
mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here …
Biomimetic nanoparticle synchronizing pyroptosis induction and mitophagy inhibition for anti-tumor therapy
Y Deng, F Jia, P Jiang, L Chen, L **ng, X Shen, L Li… - Biomaterials, 2023 - Elsevier
Inducing pyroptosis in cancer cells can result in a strong anti-tumor immune response. Our
preliminary study indicates that pyroptosis can be temporarily strengthened by disrupting …
preliminary study indicates that pyroptosis can be temporarily strengthened by disrupting …
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential
N Wu, W Zheng, Y Zhou, Y Tian, M Tang, X Feng… - Ageing Research …, 2024 - Elsevier
Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …
organelles and toxic macromolecules in the cells. Regarding the essential function of …
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis
M Liu, Y Fan, D Li, B Han, Y Meng, F Chen… - Molecular …, 2021 - Wiley Online Library
Despite recent progress in non‐small‐cell lung cancer (NSCLC) treatment, treatment
outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a …
outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a …
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the
sensation of various pathogenic and non-pathogenic damage signals and has a vital role in …
sensation of various pathogenic and non-pathogenic damage signals and has a vital role in …
Mitochondria in cancer stem cells: Achilles heel or hard armor
X Zheng, J Chen, Y Sun, T Chen, J Wang, S Yu - Trends in Cell Biology, 2023 - cell.com
Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …