Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

The role of platelets in immune-mediated inflammatory diseases

M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

A compendium of single extracellular vesicle flow cytometry

JA Welsh, GJA Arkesteijn, M Bremer… - Journal of …, 2023 - Wiley Online Library
Flow cytometry (FCM) offers a multiparametric technology capable of characterizing single
extracellular vesicles (EVs). However, most flow cytometers are designed to detect cells …

Understanding the extracellular vesicle surface for clinical molecular biology

S Hallal, Á Tűzesi, GE Grau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant
roles in health and disease. EVs are abundant in body fluids and carry an array of molecules …

Circulating platelets as mediators of immunity, inflammation, and thrombosis

M Koupenova, L Clancy, HA Corkrey… - Circulation …, 2018 - ahajournals.org
Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

Modification of extracellular vesicles by fusion with liposomes for the design of personalized biogenic drug delivery systems

M Piffoux, AKA Silva, C Wilhelm, F Gazeau, D Tareste - ACS nano, 2018 - ACS Publications
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport
macromolecules throughout the body. Hijacking this endogenous communication system …

Platelet extracellular vesicles: beyond the blood

F Puhm, E Boilard, KR Machlus - Arteriosclerosis, thrombosis, and …, 2021 - ahajournals.org
Extracellular vesicles (EVs) are a means of cell-to-cell communication and can facilitate the
exchange of a broad array of molecules between adjacent or distant cells. Platelets are …

Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

E Mianehsaz, HR Mirzaei, M Mahjoubin-Tehran… - Stem cell research & …, 2019 - Springer
Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and
disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not …

Molecular interactions at the surface of extracellular vesicles

EI Buzás, EÁ Tóth, BW Sódar… - Seminars in …, 2018 - Springer
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large
oncosomes have been shown to participate in a wide variety of biological processes and are …

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

S Anand, M Samuel, S Kumar, S Mathivanan - Biochimica et Biophysica …, 2019 - Elsevier
Extracellular vesicles (EVs) are released by cells into the extracellular milieu to facilitate
intercellular communication in both physiological and pathological condition. EVs contain …