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Recent advances in chemical protein synthesis: method developments and biological applications
S Dong, JS Zheng, Y Li, H Wang, G Chen… - Science China …, 2024 - Springer
The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …
biological processes, the study of which necessitates advanced methods to produce …
[HTML][HTML] Strategies for improving peptide stability and delivery
Peptides play an important role in many fields, including immunology, medical diagnostics,
and drug discovery, due to their high specificity and positive safety profile. However, for their …
and drug discovery, due to their high specificity and positive safety profile. However, for their …
DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides
G Shi, X Kang, F Dong, Y Liu, N Zhu, Y Hu… - Nucleic acids …, 2022 - academic.oup.com
Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules
which have antimicrobial activity and potent structure stability. We previously published the …
which have antimicrobial activity and potent structure stability. We previously published the …
Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
Recent advances in ruthenium-based olefin metathesis
Ruthenium-based olefin metathesis catalysts, known for their functional group tolerance and
broad applicability in organic synthesis and polymer science, continue to evolve as an …
broad applicability in organic synthesis and polymer science, continue to evolve as an …
Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms
AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
Cell-penetrating peptides: from basic research to clinics
G Guidotti, L Brambilla, D Rossi - Trends in pharmacological sciences, 2017 - cell.com
The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …
various therapeutics often hampers systemic drug distribution; thus, most of the available …
Stapled helical peptides bearing different anchoring residues
A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …
globular protein domain; the peptides involved in surface interactions play important roles …
Macrocyclization strategies for cyclic peptides and peptidomimetics
C Bechtler, C Lamers - RSC medicinal chemistry, 2021 - pubs.rsc.org
Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …
Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …