Recent advances in chemical protein synthesis: method developments and biological applications

S Dong, JS Zheng, Y Li, H Wang, G Chen… - Science China …, 2024 - Springer
The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

[HTML][HTML] Strategies for improving peptide stability and delivery

O Al Musaimi, L Lombardi, DR Williams, F Albericio - Pharmaceuticals, 2022 - mdpi.com
Peptides play an important role in many fields, including immunology, medical diagnostics,
and drug discovery, due to their high specificity and positive safety profile. However, for their …

DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides

G Shi, X Kang, F Dong, Y Liu, N Zhu, Y Hu… - Nucleic acids …, 2022 - academic.oup.com
Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules
which have antimicrobial activity and potent structure stability. We previously published the …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Recent advances in ruthenium-based olefin metathesis

OM Ogba, NC Warner, DJ O'leary… - Chemical Society …, 2018 - pubs.rsc.org
Ruthenium-based olefin metathesis catalysts, known for their functional group tolerance and
broad applicability in organic synthesis and polymer science, continue to evolve as an …

Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms

AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …

Cell-penetrating peptides: from basic research to clinics

G Guidotti, L Brambilla, D Rossi - Trends in pharmacological sciences, 2017 - cell.com
The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

Stapled helical peptides bearing different anchoring residues

X Li, S Chen, WD Zhang, HG Hu - Chemical Reviews, 2020 - ACS Publications
A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Macrocyclization strategies for cyclic peptides and peptidomimetics

C Bechtler, C Lamers - RSC medicinal chemistry, 2021 - pubs.rsc.org
Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Intrinsically disordered proteins in cellular signalling and regulation

PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …